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Published Work

The fruits of my labor

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        International Peer-reviewed Journal Publications (Citation/article, Impact Factor)​

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  1. Das, M.* $; Oyarzabal, E. A$., Chen, L; Lee, S.H.; Shah, N; Gerlach, G; Zhang, W; Chao TH, Van Den Berg, N; Liu, C; Donley, C; Montgomery, S.; Shih, Y.Y*. One-Pot Synthesis of carboxymethyl-dextran coated iron-oxide nanoparticles (CION) for preclinical fMRI and MRA applications Accepted in Neuroimage, 2021, $ Authors contributed equally. (6.556)

  2. Singha, H.; Sreedharan, S.; Oyarzabal, E.A.; Mahapatra, T.S.; Green, N; Shih, Y.Y.I.; Das, M*, Thomas, J.A.; * Das, A; *, and Pramanik, S.K. Mitochondriotropic Lanthanide Nanorods: Implications for Multimodal Imaging  Chem. Commun., 2020 * Corresponding authors (6, 6.222)  

  3. Chen, Y.W., Das, M, Oyarzabal, E.A, Cheng, Q;  Plummer, N.W.; Smith, K.G.; Jones, G.K.; Malawsky, D; Yakel, J.L.; Shih Y.Y.I, Jensen, P et. al. Genetic identification of a population of noradrenergic neurons implicated in stress resilience Molecular Psychiatry (Nature Publishing Group) 2019, 24(5), 710-725 (16, 12.384)

  4. Chen, Y.W., Das, M, Oyarzabal, E.A, Cheng, Q; Plummer, N.W.; Smith, K.G.; Jones, G.K.; Malawsky, D; Yakel, J.L.; Shih Y.Y.I, Jensen, P et. al. A subset of noradrenergic (NE) neurons defined by developmental expression of Hoxb1 have a distinct role in attenuating the behavioral response to acute stress Published as Image in Molecular Psychiatry through Editorial Invitation 2019, 24(5), 625 (12.384)

  5. Decot, H.K; Namboodiri, V.M.K; Gao, W.; McHenry, J; Jennings, J.; Lee, SH.; Kantak, P.; Kao, Y.C.; Das, M.; Witten, I.; Deisseroth, K.; Shih, Y.Y.I; Stuber, G Coordination of brain-wide activity dynamics by dopaminergic neurons Neuropsychopharmacology 2017, 42 (3), 615-627 (50, 7.853)

  6. Das, M#; Jain, R#; Agrawal, A.K. et al. Macromolecular bipill of gemcitabine and methotrexate facilitates tumor-specific dual drug therapy with higher benefit-to-risk ratio Bioconjugate Chem. 2014, 25, 501-9 # Authors contributed equally (27, 4.47)

  7. Jain, S; Jain, R; Das M et al; Combinatorial Bio-Conjugation of Gemcitabine and Curcumin Enables Dual Drug Delivery with Synergistic Anticancer Efficacy and Reduced Toxicity RSC Advance 2014, 4, 29193-29201 (31, 3.361)

  8. Das, M Does the targeted delivery of theranostic carbon nanotubes have potential as a valid anticancer strategy? Therapeutic Delivery 2014, 05, 01 (Invited Editorial) (2) 

  9. Hatial I; Jana, S; Bisai S; Das M et al. Trienediynes on a 1, 3, 5-trisubstituted benzene template: A New Approach for Enhancement of Reactivity RSC Advance 2014, 4, 28041-28045 (4, 3.361)

  10. Das, M; Singh, R.P; Datir S et al. Intranuclear Drug Delivery and Effective in vivo Cancer Therapy via Estradiol PEG-Appended Multiwalled Carbon Nanotubes. Mol. Pharm. 2013, 10, 3404-3416 (54, 4.939)

  11. Das, M#; Singh, R.P#; Datir, S et al. Surface Chemistry Dependent “Switch” Regulates the Trafficking and Therapeutic Performance of Drug-Loaded Carbon Nanotubes Bioconjugate Chem. 2013, 23, 2201-13 # Authors contributed equally (42, 4.47) 

  12. Das, M; Datir, S; Singh, R.P et al. Augmented Anticancer Activity of a Targeted, Intracellularly Activatable, Theranostic Nanomedicine based on Fluorescent and Radiolabeled, Methotrexate-Folic acid-Multiwalled Carbon Nanotube Conjugate Mol. Pharm. 2013, 10, 2543-2557 (102, 4.939)

  13. Kumar, S; Das, M; Singh, R.P; Datir, S et al. Mathematical models for the oxidative functionalization of multiwalled carbon nanotubes, Colloids and Surfaces A: Physicochem. Eng. Aspects, 2013, 419: 156-165 (10, 4.539) 

  14. Das, M*; Bandyopadhyay, D; R Singh, R.P; Harde, H; Kumar, S; Jain, S Orthogonal biofunctionalization of magnetic nanoparticles via “clickable” poly (ethylene glycol) silanes: a “universal ligand” strategy to design stealth and target-specific nanocarriers J. Mat. Chem 2012, 22, 24652-24667 (24, 6.626)

  15. Datir, S.; Das, M.; Singh R.P. et al. Hyaluronate tethered “smart” multiwalled carbon nanotubes for tumor-targeted delivery of doxorubicin. Bioconjugate Chem. 2012, 21,2201-13 (129, 4.47)  

  16. Singh R.P.; Das, M.; Thakare, V et al. Functionalization density-dependent toxicity of oxidized multiwalled carbon nanotubes in a murine macrophage cell line Chem. Res. Toxicol., 2012, 25, 2127-37 (41, 3.739) 

  17. Jain, S.; Rathi V, V.; Jain A.K.; Das, M. et al. Folate decorated PLGA nanoparticles as a rationally designed vehicle for oral delivery of insulin Nanomedicine 2012, 7, 1311-37 (150, 5.307)

  18. Agrawal, A.K.; Das, M.; Jain, S In situ gel systems as `smart' carriers for sustained ocular drug delivery Expert Opinion on Drug Delivery 2012, 9, 383-402 (124, 6.648)

  19. Harde, H.; Das, M.; Jain, S et al. Solid Lipid Nanoparticles: An Oral Bio-availability Enhancer Vehicle. Expert Opinion on Drug Delivery 2011, 8, 1407-1424 (212, 6.648)

  20. Jain, S; Das, M Conference Scene: Nanomedicine kindles the development of “elixir of life.” Nanomedicine 2011, 6(4), 599–60 (4, 5.307) 

  21. Jain, S.; Mathur, R.; Das, M. et al. Synthesis, Pharmacoscintigraphic Evaluation and Antitumor Efficacy of Methotrexate-Loaded, Folate Conjugated, Stealth Albumin Nanoparticles Nanomedicine 2011, 6, 1733-1734 (35, 5.307) 

  22. Swarnakar, N.K.; Jain, A. K.; Singh, R. P.; Godugu, C.; Das, M.; Jain, S. Oral bioavailability, therapeutic efficacy and reactive oxygen species scavenging properties of coenzyme Q-10 loaded polymeric nanoparticles 2011, 32, 6860-6874 (132, 10.317)

  23. Jain, A.K.; Swarnakar, N.K.; Das, M.  et al.  Augmented Anticancer Efficacy of Doxorubicin Loaded Polymeric Nanoparticles after Oral Administration in Breast Cancer Induced Animal Model Mol. Pharm. 2011, 8, 11401151 (82, 4.939)

  24. Jain, S.; Thakre, V.S.; Das, M. et al. Toxicity of multiwalled carbon nanotubes with end-defects critically depends on their functionalization density Chem. Res.Toxicol. 2011, 24, 2028-2029 (155, 3.739)

  25. Bhattacharya, D.; Das, M; Mishra, D et al. Folate receptor-targeted, carboxymethyl chitosan functionalized iron oxide nanoparticles: a novel ultradispersed nanoconjugate for bimodal imaging Nanoscale 2011, 3, 16531662 (123, 7.79)

  26. Bhattacharya, D; Sahu, S.K; Banerjee, I.; Das, M et al. Synthesis, characterization, and in vitro biological evaluation of highly stable diversely functionalized superparamagnetic iron oxide nanoparticles Journal of Nanoparticle Research 2011, 13, 4173-4188 (33, 2.253)

  27. Dhak, P.; Dhak, D.; Das, M et al. A Novel Synthesis of FeNbO4 Nano-rod by Hydrothermal Process Journal of Nanoparticle Research 2011, 13, 4153-4159 (9, 2.253)

  28. Dhak P; Dhak D; Das, M. et al. Dielectric and Impedance Spectroscopy Study of Ba0.8 Bi2.133 Nb1.6 Ta0 .4 O9 Ferroelectric Ceramics, Prepared By Chemical Route, Journal of Materials Science: Materials in Electronics        2011, 12, 1750-1760 (28, 2.478)

  29. Jain, A. K.; Das, M.; Swarnakar, N.K et al. Engineered PLGA Nanoparticles: An emerging Delivery Tool in Cancer Therapeutics Crit Rev Ther Drug Carrier Syst. 2011, 28, 1-43 (113, 4.889) 

  30. Thakre, V.S.; Das, M.; Jain, A.K. et al. Carbon Nanotubes in cancer theragnosis Nanomedicine 2010, 5, 1277301(116, 5.307) 

  31. Dhak, P.; Dhak, D.; Das, M. et aI. Impedance Spectroscopy study of LaMnO3 modified BaTiO3 ceramics Materials Science and Engineering: B 2009, 164, 165-171 (92, 4.051) 

  32. Das, M.*; Mishra, D.; Dhak, P; et al. Biofunctionalized, phosphonate-grafted, ultrasmall iron oxide nanoparticles for combined targeted cancer therapy and multimodal imaging. 2009, 5, 2883-2893 (177, 13.281)

  33. Das, M.; Mishra, D.; Maiti, T. K. et al.  Bio-functionalization of magnetite nanoparticles using an amino phosphonic acid coupling agent: new, ultradispersed, iron-oxide folate nanoconjugates for cancer-specific targeting Nanotechnology 2008, 19, 415101 (137, 3.874) 

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     Book Chapter/Book

  1. Das, M.; Pramanik P Magnetic Nanoparticles in the Diagnosis and Imaging of Cancer Nanotechnology: Diagnosis and Treatment of Cancers (Chapter 4), R. Banerjee (Ed.), Narosa International Publishers, 2012, ISBN: 978-81-8487-159-3 R. Banerjee (Ed.).   

  2. Das, M., Basak, A. and Pramanik, P. Biofunctionalized Magnetic Nanoparticles for Cancer Theranostics S. Campbell (Ed.) 2012 LAP Lambert Academic Publishing House, Germany. ISBN: 9783848406319 

     

       Peer-Reviewed Conference Abstracts

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  1. Das, M., Oyarzabal, E. A., Chen, Y.W. et al. Chemogenetic fMRI and 18F-FDG PET Reveal Functional Projections of Hoxb1-Derived Noradrenergic Neurons Proc Intl Soc Mag Reson Med (2017) Oral Presentation (Summa cum Laude Merit Award) at ISMRM 25th Annual Meeting and Exhibition, Honolulu, Hawaii, USA

  2. Oyarzabal, E. A., Lee, S.H., Das, M., Song, S, Hong, J.S., and Shih, Y.Y. “How does chronic neuroinflammation affect resting-state functional connectivity?”, Proc Intl Soc Mag Reson Med (2017) ISMRM 25th Annual Meeting and Exhibition, Honolulu, Hawaii, USA. 

  3. Das, M., Oyarzabal, E. A., Decot, H. K. et al. Development of intravascular SPION with tunable pharmacokinetics and relaxivity for preclinical fMRI and micro-MRA Proc Intl Soc Mag Reson Med (2016) e-Poster presentation ISMRM 24th Annual Meeting and Exhibition, Singapore. 

  4. Oyarzabal, E. A., Das, M., Lee, S.H et al. Deciphering the Functional Role of Locus Coeruleus-derived Norepinephrine using Chemogenetic fMRI and 18FDG-PET Proc Intl Soc Mag Reson Med (2016) Oral Presentation. (Summa cum Laude Merit Award) ISMRM 24th Annual Meeting and Exhibition, Singapore. 

  5. Decot, H.K., Namboodiri, M.K.; Gao, W., MCHenry, J.H. Jennings; Lee, S.H.; Kantak, P.A., Kao, Y.C.; Das. M.; Witten, I.B., Deisseroth, K; Shih, Y.Y., Stuber, G.D. Coordination of brain-wide activity dynamics by dopaminergic neurons Society for Neuroscience (SfN) November 12-16, 2016 San Diego, CA 

  6. Decot, H.K., Gao, W., Kantak, P.A., Kao, Y.C.; Das. M.; Witten, I.B., Deisseroth, K; Shih, Y.Y., Stuber, G.D. Coordination and remodeling of cortico-limbic network dynamics by dopaminergic neuronal activity Society for Neuroscience (SfN) November 15-19, 2014 Washington, D.C. 

  7. Das, M., Decot, H. K., Kao, Y. C., Oyarzabal, E. A. & Shih, Y. Y. I. Probing Gq-GPCR Signaling in Rat Primary Motor Cortex with Pharmacogenetic fMRI Proc Intl Soc Mag Reson Med (2015) Poster Presentation at ISMRM 23rd Annual Meeting and Exhibition, Toronto, Canada. 

  8. Johns S.*, Das, M.*, Oborski, M., Laymon C.C., 18F-FLT-PET to monitor therapeutic response in glioblastoma patients Oral Presentation at Multimodal Neuroimaging Training Program Symposium 2014, Carnegie Melon University, US.

  9. Das, M.; Datir, S.; Singh, R. P.; Kumar, S.; Jain, S.  Estradiol-PEG-Appended Multiwalled Carbon Nanotubes for Estrogen Receptor Targeted, Multimodal Delivery of Anticancer Agents Poster Presentation at 39th Annual Meeting and Exposition of Controlled Release Society, Centre de Congress de Quebec, Quebec City, Canada (15th July-18th July, 2012) 

  10. Jain, S.; Rathi V, V.; Jain A.K.; Das, M. Folate Coupled Engineered Polymeric Nanoparticles as a Rationally Designed Carrier for Oral Delivery of Insulin. 39th Annual Meeting & Exposition of the Controlled Release Society, Québec City, Canada, (July 15-18, 2012) Poster presentation

  11. Jain, S.; Rathi V, V.; Das, M. Jain A.K. Oral insulin nanoparticles once-a-day: A "magic pill" to combat diabetes, Bio Asia 2012, Hyderabad India, February 9-11, 2012. (nominated for BioAsia young innovator award- 2012)

  12. Das, M.; Singh, R. P.; Datir, S.; Kumar, S.; Jain, S. Design, Synthesis and Biological Evaluation of a Novel, Multifunctional, Carbon Nanotube based “Smart” Drug Delivery Platform” selected for Oral presentation at The 38th Annual Meeting and Exposition of Controlled Release Society, National Harbor, Maryland USA. 

  13. Das, M. Novel Strategies to Design “Smart” Theragnostic Magnetic Nanoparticles: From Tailored Surface to Theragnostics Invited Talk in Second World Conference for Nanomedicine and Drug Delivery WCN 2011, Kottayam, Kerala (India). 

  14. Swarnakar, N.K.; Jain, A.K.; Singh, R.P.; Godugu, C.; Das, M.; Jain, S. Preparation, In Vitro and In Vivo Evaluation of CoQ10 Loaded Cationic Polymeric Nanoparticles: A Potential Reactive Oxygen Species Scavenger, Fourth Winter School on Nanotechnology for Advanced Drug Delivery, February 28-March 4, NIPER, SAS NAGAR, Mohali, Punjab, India. (Budding Nanotechnologist Award).

  15. Das, M.; Basak, A.; Pramanik, P. A “Click Chemistry” Approach to the design of a Multifunctional Nanomedicine for “Smart” Cancer Diagnosis and Therapy Oral Presentation in Second Summer School on Nanotechnology for Advanced Drug Delivery, August 10-14 2009 NIPER, SAS NAGAR, Mohali, Punjab. 

  16. P. Dhak, D. Dhak, M. Das and P. Pramanik “Dielectric diffuseness and impedance spectroscopy of nanocrystalline Ba0.8Cu0.2Ti0.8(AlK)0.2O3 ferroelectric ceramics prepared by chemical route” International Conference on Nnanomaterials: Synthesis, Characterization and Applications (27-29th April 2010), Center for Nanoscience and Nanotechnology, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India.

  17. Das, M.; Pramanik, P.; Development of surface-engineered superparamagnetic nanoparticles for targeted cancer therapy Oral Presentation in Second Winter School on Nanotechnology for Advanced Drug Delivery, Feb 24-28 2009 NIPER, SAS NAGAR, Mohali, Punjab. 

  18. Das, M.; Pramanik. P.; Basak, A. Highly Water-Soluble Magnetofluorescent Iron-Oxide Nanoparticles for Cancer-Specific Targeting: Synthesis, Characterization and In-vitro Studies Poster Presentation in International Symposium on Frontiers of Functional Materials (ISFFM-2009), January 6-7 2009, Calcutta University, Kolkata (India). 

  19. Das, M.; Pramanik. P. Recent advancement in the use of iron-oxide nanoparticles for purification of recombinant protein and targeting cancer cells Oral Presentation in Workshop on Nanotechnology: An interaction session with Eric Drexler, Father of Nanotechnology at IIT Kharagpur 

  20. Das, M.; Basak, A.; Pramanik, P.; A Multifunctional Superparamagnetic Nanodevice for “Smart” Cancer- Diagnosis and Therapy Poster Presentation in DAE-BRNS, International Symposium on Materials Chemistry (ISMC-2008), December 2-6 2008, BARC, Mumbai. 

  21. Das, M.; Basak, A.; Pramanik; P. Recent development in the use of superparamagnetic iron-oxide nanoparticles for “smart” cancer diagnostics and therapeutics Oral Presentation in National Seminar on Current Trends in Chemistry-II, March 4, 2008, Kalyani University, Kalyani, West Bengal (India) )                                                                                                                          

      Patents

  1. S. Jain, D.S. Chauhan, A. K. Jain, N. K. Swarnakar, H. Harde, R.R. Mahajan, D. Kumar, P.K. Valvi, M. Das, S.R. Datir, K. Thanki. A process for stabilization of nano-drug delivery systems by lyophilization. Patent no: 306846; Granted on 05.02.2019 Application no.: 2559/DEL/2011 filed on September 06, 2011. 

  2.  S. Jain, V. Rathi, M. Das, A. K. Jain. Folic acid conjugated polymeric nanoparticles for oral delivery of Insulin. Application no.: 2202/DEL/2011 filed on August 03, 2011.                             

Glimpses  of my  recent work

One-pot synthesis of carboxymethyl-dextran coated iron oxide nanoparticles (CION) for preclinical fMRI and MRA applications

CION-fMRI.png

Chemogenetic Stimulation of Tonic Locus Coeruleus Activity Strengthens the Default Mode Network

NE-LC.png

A subset of noradrenergic (NE) neurons defined by developmental expression of Hoxb1 have a distinct role in attenuating the behavioral response to acute stress

NE_Hoxb1.png

Genetic identification of a population of noradrenergic neurons implicated in attenuation of stress-related responses

NE_Hoxb2.png

Mitochondriotropic lanthanide nanorods: implications for multimodal imaging

Mitochondriotopic nanorods_1.png
Mitochondriotopic nanorods_2.png

Coordination of Brain-Wide Activity Dynamics by Dopaminergic Neurons

Opto.png
Get in Touch
Image by Robert Lukeman

 

Awards and Honors

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  • 2019: Invitation to join Consultative Group of Primary Scientific Advisor, Govt. of India to provide intellectual inputs on National Science Policy on various socio-economic issues.

  • 2017: Summa Cum Laude Merit Award from International Society for Magnetic Resonance in Medicine (ISMRM, the largest meeting in the world dedicated to MRI) for the work, “Chemogenetic fMRI and 18F-FDG PET Reveal Functional Projections of Hoxb1-Derived Noradrenargic Neurons”. 

  • 2015, 2016, 2017: Educational Stipend Award for 3 consecutive years for significant contribution in the area of chemogenetic fMRI and new MRI contrast agent development. 

  • 2014-2017: Cross disciplinary fellowship (CDF) grant award from international Human Frontier Science Program Organization (HFSPO) for dissecting the neuronal and astrocytic component of BOLD-fMRI signal using chemogenetic and optogenetic fMRI

  • 2014: Training award for participation in the highly competitive NIH-sponsored Multimodal Neuroimaging Training Program at University of Pittsburgh and Carnegie Melon University 

  • 2012: International travel grant award, Indian Council of Medical Research (ICMR), Department of 

  • Biotechnology (DBT) and Department of Science and Technology (DST), Government of India (GOI)

  • 2012: DST Postdoctoral Fellowship in Nanoscience and Nanotechnology, DST, GOI

  • 2011: International travel grant award ICMR and Council of Scientific and Industrial Research (CSIR, GOI) 

  • 2008: Travel stipend for participation in Science Conclave: A congregation of Nobel Laureates, DST-GOI 

  • 2005: Junior Research Fellowship (JRF) and Senior Research Fellowship in Chemical Science by CSIR, GOI  

  • 2005: Scored 98.35 percentile in Graduate Aptitude Test to Engineering (GATE); All India Rank 57, Chemical Science.

  • 2003: National Scholarship, GOI for securing 1st class in B.Sc. Final Examination

  • 2000: Binoy Krishna Modok Trust Fund Scholarship (Mathematics Topper in High School), Hooghly Mohsin 

  • College, India 

  • 1998: National Prize for securing 55th rank in Secondary (school leaving) Examination among 600000 candidates 

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